What is 5-AMINO-1MQ?
5-amino-1MQ is a small-molecule drug that works by blocking the activity of an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT plays a significant role in metabolism and energy and is active mainly in adipose tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as the "longevity gene" for its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis, and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.
Simply put,
This means that 5-amino-1MQ allows your body to burn fat for energy, while prioritizing the maintenance of muscle mass. 5-amino-1MQ is safe and effective for reversing and preventing diet-induced obesity. It is a potentially better treatment option for individuals with type 2 diabetes (or at risk) and other metabolic comorbidities of obesity. In addition, activation of SIRT1 through increased NAD+ suggests that 5-amino-1MQ is a good choice for patients who want to develop
comprehensive anti-aging protocol.
There is a critical need for new drugs with a mechanism of action that reduces the burden of obesity, osteoarthritis, cardiovascular disease, cancer, Parkinson's disease, kidney disease, metabolic disorders, and other related chronic metabolic comorbidities.
Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme with a recently identified role in cellular metabolism and energy homeostasis. Studies show that this enzyme slows down the process by which our body metabolizes fat cells. Most people have trouble losing weight, and when this enzyme is elevated, it is more difficult for them to try to shed pounds of excess fat. Being overweight leads to an increase in the enzyme NNMT, which leads to a slowdown in fat metabolism, which leads to excessive weight gain. It's a vicious circle. Research suggests that the potent NNMT inhibitor "5-amino-1mq" significantly reduced body weight and white fat mass, reduced adipocyte size, and reduced total plasma cholesterol levels.
These findings support the development of small-molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target for the treatment of obesity and related metabolic conditions.
Advantages:
NNMT inhibitors as a therapy to reverse diet-induced obesity.
NNMT is a valid target for the treatment of obesity and related metabolic diseases.
Prevent adipogenesis and reverse obesity caused by diet. NNMT expression is upregulated in white adipose tissue (WAT). It has significantly higher activity in WAT compared to activity in brown adipose tissue, liver and lungs.
NNMT inhibitors had no effect on food intake. However, they have shown significant reductions in body weight, WAT weight, adipocyte size, and cholesterol levels with negligible ... (here the text ended in the provided copy)...
